

OVITRELLE
Active Ingredient: Choriogonadotropin Alfa (recombinant hCG)
Dosage: 250mcg/0.5mL pre-filled syringe
Manufacturer: Merck Serono
What Is Ovitrelle (Ovidrel)?
Ovitrelle (also known as Ovidrel in the United States) is a recombinant hCG trigger shot used during fertility treatment.
How Does the HCG Trigger Shot Work?
Ovitrelle works by mimicking your body’s natural LH surge – the hormone spike that normally triggers ovulation. After taking ovarian stimulation medications like Gonal-F or Menopur for 8-12 days, your eggs need one final signal to mature completely.
The hCG injection causes eggs to undergo their final maturation within 36-40 hours. This precise timing allows your fertility team to schedule egg retrieval at exactly the right moment – when eggs are mature but haven’t yet been released from your ovaries.
When Do You Take the Ovidrel Trigger Shot?
Timing is everything with Ovitrelle. Your doctor determines the exact day and time based on ultrasound monitoring and blood tests that track follicle size and estrogen levels. Most patients receive instructions to inject Ovitrelle late at night – often between 9 PM and midnight.
If you’re using Orgalutran or another GnRH antagonist to prevent premature ovulation, you’ll typically stop those injections the same day you take your trigger shot. Your clinic will provide specific timing instructions tailored to your protocol.
How to Administer Ovitrelle Injection
Ovidrel comes as a ready-to-use pre-filled syringe, making administration simpler than medications requiring mixing. You’ll inject it subcutaneously – under the skin of your lower abdomen or upper thigh.
Your healthcare provider will demonstrate proper injection technique, or you can watch our detailed step-by-step injection videos. Most patients find the trigger shot less intimidating than daily stimulation injections since its only given once per cycle.
Who Should Not Use Ovitrelle?
Ovitrelle (Ovidrel) is contraindicated in women with:
- Prior hypersensitivity to hCG preparations or ingredients
- Primary ovarian failure
- Uncontrolled thyroid or adrenal dysfunction
- Pituitary tumor or intracranial lesion
- Abnormal uterine bleeding of unknown origin
- Ovarian cyst or enlargement of unknown cause
- Hormone-dependent tumors of reproductive organs
- Current pregnancy
Always inform your fertility specialist about your complete medical history before starting any trigger shot medication.
Frequently Asked Questions About Ovidrel Trigger Shot
What happens after I take the hCG trigger shot?
After your Ovitrelle injection, your eggs complete their final maturation over the next 36-40 hours. For IVF cycles, you’ll have your egg retrieval procedure scheduled precisely 36 hours after your trigger shot. For IUI or timed intercourse cycles, you’ll have the procedure or intercourse scheduled according to your doctor’s timing.
Does Ovitrelle need to be refrigerated?
Yes, Ovidrel should be stored in the refrigerator at 2-8°C (36-46°F) until you’re ready to use it. However, you can let it sit at room temperature for about 30 minutes before injection for added comfort. Check our guide on proper storage of fertility medications.
Can I take a pregnancy test after my trigger shot?
You should wait at least 10-14 days after your Ovitrelle injection before taking a pregnancy test. The hCG in the trigger shot will cause false positive results if you test too early, since pregnancy tests detect hCG in your system.
What are side effects of the hCG trigger shot?
Most women experience minimal side effects from Ovidrel. Common reactions include mild injection site tenderness, headache, fatigue, or mood changes. Some women feel abdominal bloating or mild cramping as eggs mature. Serious side effects are rare but require immediate medical attention.
Is Ovitrelle available for international delivery?
Yes, Fast IVF ships Ovidrel (Ovitrelle) worldwide with guaranteed on-time delivery and proper temperature-controlled packaging. We source all medications from licensed European pharmacies and offer discounted prices compared to US fertility pharmacies.
Ovitrelle is available through Fast IVF pharmacy with worldwide shipping. All hCG trigger shot medications are shipped with ice packs and temperature monitoring to ensure effectiveness. Contact our team for personalized pricing and delivery information.
