LUPRON 11.25 MG

Lupron 11.25 MG (3 Months) – Depot for IVF Down-Regulation

What is Lupron 11.25 MG?

Lupron 11.25 mg contains leuprolide acetate. This is a synthetic version of GnRH (gonadotropin-releasing hormone). It temporarily shuts down your body’s natural hormone production.

Lupron treats various medical conditions. Fertility clinics use it for a specific purpose. It prevents premature ovulation during IVF. It also creates ideal conditions for controlled ovarian stimulation.

3-Month vs. 1-Month Depot

This 3-month depot differs from the Lupron 3.75 mg 1-month version. The 11.25 mg depot releases medication slowly over 12 weeks. This makes it suitable for:

• Women who need extended suppression before starting their IVF protocol
• Specific medical conditions requiring longer treatment
• Endometriosis or fibroid management before IVF

How Lupron Works in IVF Protocols

When you first start Lupron 11.25 mg, something interesting happens. It initially stimulates your pituitary gland. This causes a temporary surge in FSH and LH.

After about 10-14 days, the process changes. The overstimulation causes your pituitary to become desensitized. Your natural hormone production shuts down. This is called “down-regulation.”

Why Down-Regulation Matters

Down-regulation gives your fertility doctor complete control over your cycle. Here’s what it does:

• Suppresses your natural hormones
• Prevents premature ovulation
• Allows stimulation medications to work better
• Helps time egg retrieval precisely

Your doctor can use medications like Gonal-F or Menopur more effectively. There’s no worry about your body releasing eggs too early.

Lupron Depot 11.25 MG vs 3.75 MG: Which Do You Need?

The main difference is duration.

Lupron 11.25 mg:

• Provides 3 months of suppression
• Single injection
• Used for extended suppression needs

Lupron 3.75 mg:

• Lasts only 1 month
• Monthly injections
• Common for standard IVF cycles

Most IVF patients use the shorter-acting version. Typical IVF cycles dont require 3 months of suppression.

When You Might Need the 11.25 mg Depot

Your doctor might prescribe this stronger dose if you have:

• Endometriosis
• Large fibroids
• Severe PCOS

These conditions need extended suppression before starting IVF stimulation. Some protocols use it 2-3 months before the actual IVF cycle. This helps shrink fibroids or quiet endometriosis.

Administration and Dosage for IVF

Lupron 11.25 mg is given as an intramuscular injection. A healthcare professional gives the shot. They inject it in your buttock or thigh muscle.

Unlike daily Lupron injections or the monthly depot, this is simple. One single injection provides continuous hormone suppression for 12 weeks.

Typical IVF Protocol Timing

• Injection given 2-3 months before planned IVF cycle start
• Down-regulation confirmed through blood work (low estradiol levels)
• Ultrasound shows thin uterine lining and quiet ovaries
• Stimulation medications start once suppression is confirmed
• Often combined with birth control pills initially

Lupron Depot Side Effects

Lupron 11.25 mg creates a temporary menopause-like state. It shuts down estrogen production. Most women experience menopausal symptoms during treatment.

Common Side Effects

• Hot flashes
• Night sweats
• Mood changes
• Headaches
• Vaginal dryness
• Decreased libido

These effects can be stronger with the 3-month depot. The extended suppression period causes this. Some doctors prescribe “add-back therapy” with small amounts of estrogen. This reduces symptoms while maintaining adequate suppression for IVF.

When to Call Your Doctor

Contact your fertility specialist if you experience:

• Severe headaches
• Vision changes
• Bone pain
• Signs of depression

Who Should Use Lupron Depot 11.25 MG?

The 3-month depot works best for specific conditions. Its typically prescribed for women with:

• Endometriosis
• Uterine fibroids
• Adenomyosis

These women need extended suppression before IVF. Its less common for standard IVF cycles. The 1-month depot or daily Lupron injections usually work better for regular cycles.

Who Should Not Use Lupron

Don’t use Lupron if you:

• Are pregnant or breastfeeding
• Have undiagnosed vaginal bleeding
• Are allergic to GnRH agonists

Always tell your doctor about all medications and supplements you’re taking.

Frequently Asked Questions

What’s the difference between Lupron and Lucrin Depot?

Lupron 11.25 mg and Lucrin Depot 11.25 mg are the same medication. They both contain leuprolide acetate. They’re just marketed under different brand names in different countries.

Other equivalent names include:

• Enantone
• Procrin

All contain the same active ingredient. They work identically for IVF suppression protocols.

How much does Lupron 11.25 mg cost?

Lupron Depot prices vary significantly. US pharmacies charge much more than European ones.

At Fast IVF, we offer competitive pricing on European-sourced Lupron 11.25 mg depot. Contact our pharmacy team for current pricing. Or request a fast quote for your complete medication protocol.

Can I use the 3-month depot for a regular IVF cycle?

Most standard IVF cycles use different options:

• 1-month depot
• Daily Lupron injections

The 11.25 mg depot is typically reserved for special cases. Women needing extended suppression use it. This includes treating endometriosis or fibroids before starting IVF.

Your fertility doctor will determine which formulation best suits your protocol.

When will my period return after Lupron Depot?

After the 3-month Lupron Depot wears off, timing varies. Most women get their period within 4-8 weeks.

However, IVF has different timing. If you’re starting IVF stimulation medications right after suppression, your doctor won’t wait. They’ll induce a period with medication rather than waiting for it to return naturally.

Recovery time varies based on individual hormone levels.

Is Lupron Depot safe for long-term use?

Lupron Depot is safe for the time periods prescribed by your doctor. For IVF, you typically use it for 3-6 months maximum. Extended use beyond 6 months may affect bone density. Your doctor monitors this closely.

Will Lupron affect my future fertility?

No. Lupron’s effects are temporary. Your natural hormone production returns after the medication wears off. Many women successfully get pregnant through IVF after using Lupron. It doesn’t damage your ovaries or eggs.

Important: Use Lupron 11.25 mg only under a qualified fertility specialist’s supervision. This information is educational and doesn’t replace medical advice from your healthcare provider.